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Alternative Market Briefing

Significance Capital launches with proprietary models targeting market turning points

Tuesday, March 31, 2026

Matthias Knab, Opalesque for New Managers:

Milwaukee-based Significance Capital Management LLC has launched as a registered investment adviser, introducing an investment approach built around identifying market turning points through a combination of fundamental, quantitative, and technical analysis.

The firm is led by Founder and Chief Investment Officer Ryan Isherwood, CFA, CMT, and Co-Portfolio Manager Michael W. Klenn, CFA, CMT. The two previously worked together for more than a decade building momentum-driven investment strategies at Timpani Capital Management and later Calamos Investments.

Momentum, Mean Reversion, and the Turning Point Between Them

Significance Capital's investment process centers on identifying asymmetric opportunities across equity and other asset classes by analyzing the interaction between momentum and mean reversion - two forces the firm sees as the primary drivers of market cycles. Isherwood developed the underlying philosophy over more than two decades managing growth-oriented strategies.

"Markets move through cycles driven by momentum and mean reversion. Identifying the turning points between those regimes is where we believe a significant opportunity exists," said Isherwood. "Our approach is built around using every tool available - fundamental, quantitative, and technical - to understand how risk is evolving in markets. O......................

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